Thiocolchicoside
Cat. No.：YN360922
CAS No. ：602-41-5
| 产品名称: | Thiocolchicoside |
| CAS No.: | 602-41-5 |
| Chemical Name: | N-[(7S)-3-(β-D-glucopyranosyloxy)-5,6,7,9-tetrahydro-1,2-dimethoxy-10-(methylthio)-9-oxobenzo[a]heptalen-7-yl]-acetamide |
| Synonyms: | 硫秋水仙苷 |
| 分子量: | 563.62 |
| 分子式: | C₂₇H₃₃NO₁₀S |
| SMILES: | CSC1=CC=C2C3=C(OC)C(OC)=C(O[C@@H]4O[C@H](CO)[C@@H](O)[C@H](O)[C@H]4O)C=C3CC[C@H](NC(C)=O)C2=CC1=O |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Thiocolchicoside 是中枢神经系统中竞争性的 γ-氨基丁酸 A 型 (GABAA) 受体拮抗剂和甘氨酸受体激动剂。 Thiocolchicoside 是秋水仙碱的半合成硫衍生物。Thiocolchicoside 是一种肌肉松弛剂，具有抗炎和镇痛作用。 |
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Carta, M., Murru, L., Botta, P., et al.The muscle relaxant thiocolchicoside is an antagonist of GABAA receptor function in the central nervous systemNeuropharmacology51(4),805-815(2006)
Cimino, M., Marini, P., and Cattabeni, F.Interaction of thiocolchicoside with [3H]strychnine binding sites in rat x spinal cord and brainstemEur. J. Pharmacol.318(1),201-204(1996)
Reuter, S., Prasad, S., Phromnoi, K., et al.Thiocolchicoside exhibits anticancer effects through downregulation of NF-κB pathway and its regulated gene products linked to inflammation and cancerCancer Prev. Res. (Phila)3(11),1462-1472(2010)
