(-)-Securinine
Cat. No.：YN360964
CAS No. ：5610-40-2
| 产品名称: | (-)-Securinine |
| CAS No.: | 5610-40-2 |
| Chemical Name: | (6S,11aR,11bS)-9,10,11,11a-tetrahydro-8H-6,11b-methanofuro[2,3-c]pyrido[1,2-a]azepin-2(6H)-one |
| Synonyms: | 一叶秋碱 |
| 分子量: | 217.26 |
| 分子式: | C₁₃H₁₅NO₂ |
| SMILES: | O=C(O1)C=C2[C@@]13[C@](CCCC4)([H])N4[C@](C3)([H])C=C2 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | (-)-Securinine 是一种植物来源的生物碱，也是一种GABAA受体拮抗剂。 |
| IC50和靶点: | |
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Beutler, J.A., Karbon, E.W., Brubaker, A.N., et al.Securinine alkaloids: A new class of GABA receptor antagonistBrain Res.330(1),135-140(1985)
Xia, Y.-H., Chang, C.-R., Yao, S.-Y., et al.L-securinine induced the human colon cancer SW480 cell autophagy and its molecular mechanismFitoterapia82(8),1258-1264(2011)
Han, S., Zhang, G., Li, M., et al.L-securinine induces apoptosis in the human promyelocytic leukemia cell line HL-60 and influences the expression of genes involved in the PI3K/AKT/mTOR signaling pathwayOncol. Rep.31(5),2245-2251(2014)
Tao, S.-C., Peng, J.-Z., and Lu, M.-W.Central convulsive action of l-securinineZhongguo Yao Li Xue Bao.7(1),9-12(1986)
