GSK621
Cat. No.：YN420012
CAS No. ：1346607-05-3
规格
价格(RMB)
库存
| 产品名称: | GSK621 |
| CAS No.: | 1346607-05-3 |
| Chemical Name: | 6-chloro-5-(2'-hydroxy-3'-methoxy[1,1'-biphenyl]-4-yl)-3-(3-methoxyphenyl)-1H-pyrrolo[3,2-d]pyrimidine-2,4(3H,5H)-dione |
| Synonyms: | |
| 分子量: | 489.91 |
| 分子式: | C₂₆H₂₀ClN₃O₅ |
| SMILES: | O=C1NC2=C(N(C3=CC=C(C4=CC=CC(OC)=C4O)C=C3)C(Cl)=C2)C(N1C5=CC=CC(OC)=C5)=O |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | GSK621 是特异性的AMPK激动剂，其对 AML 细胞系的IC50值为13-30 μM。GSK621 可诱导自噬和凋亡。GSK621 可诱导eiF2α磷酸化 (UPR 激活的一个标志)。 |
| IC50和靶点: | |
| In Vitro: | |
| In Vivo: | |
| Clinical Trial: | |
| Solvent & Solubility: |
Sujobert, P., Poulain, L., Paubelle, E., et al.Co-activation of AMPK and mTORC1 induces cytotoxicity in acute myeloid leukemiaCell Rep.11(9),1446-1457(2015)
