DC260126
Cat. No.：YN320206
CAS No. ：346692-04-4
| 产品名称: | DC260126 |
| CAS No.: | 346692-04-4 |
| Chemical Name: | N-(4-butylphenyl)-4-fluoro-benzenesulfonamide |
| Synonyms: | DC 260126;N-(4-Butylphenyl)-4-fluoro-benzenesulfonamide;DC260126 |
| 分子量: | 307.38 |
| 分子式: | C₁₆H₁₈FNO₂S |
| SMILES: | O=S(C1=CC=C(F)C=C1)(NC2=CC=C(CCCC)C=C2)=O |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | DC260126 是一种有效的GPR40 (FFAR1)拮抗剂。DC260126 剂量依赖性地抑制亚油酸、油酸、棕榈油酸和月桂酸刺激的 GPR40 介导的 Ca2+升高 (IC50分别 6.28, 5.96, 7.07, 4.58 μM)。DC260126 对棕榈酸酯诱导的内质网应激和凋亡 (apoptosis) 有保护作用。 |
| IC50和靶点: | |
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Hu, H., He, L.y., Gong, Z., et al.A novel class of antagonists for the FFAs receptor GPR40Biochem. Biophys. Res. Commun.390(3),557-563(2009)
Sun, T., Wang, T., Zhou, Y., et al.DC260126: A small-molecule antagonist of GPR40 that protects against pancreatic β-Cells dysfunction in db/db micePLoS One8(6),(2013)
