TUG-424
Cat. No.：YN320859
| 产品名称: | TUG-424 |
| CAS No.: | 1082058-99-8 |
| Chemical Name: | 4-[2-(2-methylphenyl)ethynyl]-benzenepropanoic acid |
| Synonyms: | TUG424 |
| 分子量: | 264.32 |
| 分子式: | C₁₈H₁₆O₂ |
| SMILES: | OC(CCC(C=C1)=CC=C1C#CC2=C(C)C=CC=C2)=O |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | TUG-424 是一种有效且选择性的游离脂肪酸受体 1(FFA1/GPR40)激动剂，EC50为 32 nM。TUG-424 在 100 nM 处显著增加葡萄糖刺激的胰岛素分泌。TUG-424 可能有助于探索 FFA1 在糖尿病或肥胖等代谢性疾病中的作用。 |
| IC50和靶点: | |
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| Solvent & Solubility: |
Christiansen, E., Urban, C., Merten, N., et al.Discovery of potent and selective agonists for the free fatty acid receptor 1 (FFA1/GPR40), a potential target for the treatment of type II diabetesJ. Med. Chem.51(22),7061-7064(2008)
