TUG-770
Cat. No.：YN321016
CAS No. ：1402601-82-4
| 产品名称: | TUG-770 |
| CAS No.: | 1402601-82-4 |
| Chemical Name: | 4-[2-[2-(cyanomethyl)phenyl]ethynyl]-2-fluoro-benzenepropanoic acid |
| Synonyms: | TUG770; TUG 770 |
| 分子量: | 307.32 |
| 分子式: | C₁₉H₁₄FNO₂ |
| SMILES: | FC1=C(CCC(O)=O)C=CC(C#CC2=C(CC#N)C=CC=C2)=C1 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | TUG-770 是一种有效的，选择性的，具有口服活性的GPR40/FFA1激动剂，对人FFA1的EC50为 6 nM。TUG-770 对FFA1的选择性高于 FFA2，FFA3，FFA4，PPARγ，其他受体，转运蛋白和酶。TUG-770 可用于 2 型糖尿病研究。 |
| IC50和靶点: | |
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Christiansen, E., Hansen, S.V.F., Urban, C., et al.Discovery of TUG-770: A highly potent free fatty acid receptor 1 (FFA1/GPR40) agonist for treatment of type 2 diabetesACS Med. Chem. Lett.4(5),441-445(2013)
