Fasiglifam
Cat. No.：YN320274
CAS No. ：1000413-72-8
| 产品名称: | Fasiglifam |
| CAS No.: | 1000413-72-8 |
| Chemical Name: | (3S)-6-[[2',6'-dimethyl-4'-[3-(methylsulfonyl)propoxy][1,1'-biphenyl]-3-yl]methoxy]-2,3-dihydro-3-benzofuranacetic acid |
| Synonyms: | TAK-875 |
| 分子量: | 524.63 |
| 分子式: | C₂₉H₃₂O₇S |
| SMILES: | CC1=C(C(C)=CC(OCCCS(C)(=O)=O)=C1)C2=CC(COC3=CC=C4[C@@H](COC4=C3)CC(O)=O)=CC=C2 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Fasiglifam (TAK-875) 是一种有效的，可口服的，具有选择性的GPR40激动剂，EC50值为 72 nM。 |
| IC50和靶点: | |
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| Solvent & Solubility: |
Briscoe, C.P., Tadayyon, M., Andrews, J.L., et al.The orphan G protein-coupled receptor GPR40 is activated by medium and long chain fatty acidsJ. Biol. Chem.278(13),11303-11311(2003)
Itoh, Y., Kawamata, Y., Harada, M., et al.Free fatty acids regulate insulin secretion from pancreatic β cells through GPR40Nature422(6928),173-176(2003)
Steneberg, P., Rubins, N., Bartoov-Shifman, R., et al.The FFA receptor GPR40 links hyperinsulinemia, hepatic steatosis, and impaired glucose homeostasis in mouseCell Metab.1(4),245-258(2005)
Christiansen, E., Due-Hansen, M.E., Urban, C., et al.Free fatty acid receptor 1 (FFA1/GPR40) agonists: Mesylpropoxy appendage lowers lipophilicity and improves ADME propertiesJ. Med. Chem.55(14),6624-6628(2012)
