Xevinapant
Cat. No.：YN270304
CAS No. ：1071992-99-8
| 产品名称: | Xevinapant |
| CAS No.: | 1071992-99-8 |
| Chemical Name: | (5S,8S,10aR)-N-(diphenylmethyl)decahydro-5-[[(2S)-2-(methylamino)-1-oxopropyl]amino]-3-(3-methyl-1-oxobutyl)-6-oxo-pyrrolo[1,2-a][1,5]diazocine-8-carboxamide |
| Synonyms: | AT-406; Debio 1143; SM-406 |
| 分子量: | 561.71 |
| 分子式: | C₃₂H₄₃N₅O₄ |
| SMILES: | O=C([C@@H]1CC[C@@](CCN(C(CC(C)C)=O)C[C@@H]2NC([C@@H](NC)C)=O)([H])N1C2=O)NC(C3=CC=CC=C3)C4=CC=CC=C4 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Xevinapant (AT-406) 是一种有效的，可口服的 Smac 模拟物，为IAPs的拮抗剂，能够抑制 XIAP，cIAP1 和 cIAP2 蛋白，Ki值分别为 66.4，1.9 和 5.1 nM。 |
| IC50和靶点: | [{name:"cIAP1:1.9 nM (Ki)"},{name: "cIAP2:5.1 nM (Ki)"},{name: "XIAP:66.4 nM (Ki)"}] |
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Cai, Q., Sun, H., Peng, Y., et al.A potent and orally active antagonist (SM-406/AT-406) of multiple inhibitor of apoptosis proteins (IAPs) in clinical development for cancer treatmentJ. Med. Chem.54(8),2714-2726(2011)
Brunckhorst, M.K., Lerner, D., Wang, S., et al.AT-406, an orally active antagonist of multiple inhibitor of apoptosis proteins, inhibits progression of human ovarian cancerCancer Biol.Ther.13(9),804-811(2012)
