BV6
Cat. No.：YN270350
CAS No. ：1001600-56-1
| 产品名称: | BV6 |
| CAS No.: | 1001600-56-1 |
| Chemical Name: | 4,4'-(1,6-hexanediyl)bis[N-methyl-L-alanyl-(2S)-2-cyclohexylglycyl-L-prolyl-β-phenyl-L-phenylalaninamide |
| Synonyms: | BV-6;BV 6;Dianemycin, monosodium salt;4,4'-(1,6-Hexanediyl)bis[N-methyl-L-alanyl-(2S)-2-cyclohexylglycyl-L-prolyl-beta-phenyl-L-phenylalaninamide;BV6;N,N'-(hexane-1,6-diyl)bis(1-{(2S)-2-cyclohexyl-2-[(N-methyl-L-alanyl)amino]acetyl}-L-prolyl-beta-phenyl-L |
| 分子量: | 1205.57 |
| 分子式: | C₇₀H₉₆N₁₀O₈ |
| SMILES: | O=C(NCCCCCCNC([C@@H](NC([C@H](CCC1)N1C([C@H](C2CCCCC2)NC([C@H](C)NC)=O)=O)=O)C(C3=CC=CC=C3)C4=CC=CC=C4)=O)[C@@H](NC([C@H](CCC5)N5C([C@H](C6CCCCC6)NC([C@H](C)NC)=O)=O)=O)C(C7=CC=CC=C7)C8=CC=CC=C8 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | BV6 是cIAP1和XIAP拮抗剂。 |
| IC50和靶点: | |
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| Solvent & Solubility: |
Varfolomeev, E., Blankenship, J.W., Wayson, S.M., et al.IAP antagonists induce autoubiquitination of c-IAPs, NF-κB activation, and TNFα-dependent apoptosisCell131(4),669-681(2007)
Li, W., Li, B., Giacalone, N.J., et al.BV6, an IAP antagonist, activates apoptosis and enhances radiosensitization of non-small cell lung carcinoma in vitroJ. Thorac. Oncol.6(11),1801-1809(2011)
Schirmer, M., Trentin, L., Queudeville, M., et al.Intrinsic and chemo-sensitizing activity of SMAC-mimetics on high-risk childhood acute lymphoblastic leukemiaCell Death Dis.7:e2052,(2016)
