SM-164
Cat. No.：YN270330
CAS No. ：957135-43-2
| 产品名称: | SM-164 |
| CAS No.: | 957135-43-2 |
| Chemical Name: | (3S,3′S,6S,6′S,10aS,10′aS)-N,N′-[1,4-phenylenebis[4,1-butanediyl-1H-1,2,3-triazole-1,4-diyl[(S)-phenylmethylene]]]bis[decahydro-6-[[(2S)-2-(methylamino)-1-oxopropyl]amino]-5-oxo-pyrrolo[1,2-a]azocine-3-carboxamide |
| Synonyms: | SM-164,SM 164,SM164 |
| 分子量: | 1121.42 |
| 分子式: | C₆₂H₈₄N₁₄O₆ |
| SMILES: | C[C@H](NC)C(N[C@H]1CCCC[C@](CC[C@H]2C(N[C@@H](C3=CC=CC=C3)C4=CN(CCCCC5=CC=C(CCCCN6N=NC([C@@H](NC([C@@H]7CC[C@@](CCCC[C@@H]8NC([C@@H](NC)C)=O)([H])N7C8=O)=O)C9=CC=CC=C9)=C6)C=C5)N=N4)=O)([H])N2C1=O)=O |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | SM-164 是一种可渗透细胞的 Smac 类似物。SM-164 与含有 BIR2 和 BIR3 结构域的XIAP蛋白结合，IC50值为 1.39 nM，SM-164 用作XIAP的强效拮抗剂。 |
| IC50和靶点: | [{name:"cIAP-1:0.31 nM (Ki)"},{name: "cIAP-2:1.1 nM (Ki)'}, 'cIAP'] |
| In Vitro: | |
| In Vivo: | |
| Clinical Trial: | |
| Solvent & Solubility: |
Sun, H., Nikolovska-Coleska, Z., Lu, J., et al.Design, synthesis, and characterization of a potent, non-peptide, cell-permeable, bivalent Smac mimetic that concurrently targets both the BIR2 and BIR3 domains in XIAPJ. Am. Chem. Soc.129(49),15279-15294(2007)
Lu, J., McEachern, D., Sun, H., et al.Therapeutic potential and molecular mechanism of a novel, potent, nonpeptide, Smac mimetic SM-164 in combination with TRAIL for cancer treatmentMol. Cancer Ther.10(5),902-914(2011)
