MKC8866
Cat. No.：YN290058
CAS No. ：1338934-59-0
| 产品名称: | MKC8866 |
| CAS No.: | 1338934-59-0 |
| Chemical Name: | 7-hydroxy-6-methoxy-4-methyl-3-[2-(4-morpholinyl)-2-oxoethyl]-2-oxo-2H-1-benzopyran-8-carboxaldehyde |
| Synonyms: | IRE1-IN-8866 |
| 分子量: | 361.35 |
| 分子式: | C₁₈H₁₉NO₇ |
| SMILES: | O=CC1=C(O2)C(C(C)=C(CC(N3CCOCC3)=O)C2=O)=CC(OC)=C1O |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | MKC8866 是一种水杨醛类似物，有效的选择性IRE1 RNase抑制剂，在体外的IC50为 0.29 μM。 MKC8866 强烈抑制 Dithiothreitol 诱导的 XBP1s 表达，EC50为 0.52 μM。MKC8866 抑制无应激 RPMI 8226 细胞，IC50为 0.14 μM。 MKC8866 抑制乳腺癌细胞中的 IRE1 RNase 导致促肿瘤发生因子减少，同时也能抑制前列腺癌 (PCa) 肿瘤的生长。 |
| IC50和靶点: | |
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Sheng, X., Nenseth, H.Z., Qu, S., et al.IRE1α-XBP1s pathway promotes prostate cancer by activating c-MYC signalingNat. Commun.10(1),323(2019)
Almanza, A., Mnich, K., Blomme, A., et al.Regulated IRE1α-dependent decay (RIDD)-mediated reprograming of lipid metabolism in cancerNat. Commun.13(1),2493(2022)
