KIRA6
Cat. No.：YN290462
CAS No. ：1589527-65-0
| 产品名称: | KIRA6 |
| CAS No.: | 1589527-65-0 |
| Chemical Name: | N-[4-[8-amino-3-(1,1-dimethylethyl)imidazo[1,5-a]pyrazin-1-yl]-1-naphthalenyl]-N'-[3-(trifluoromethyl)phenyl]-urea |
| Synonyms: | KIRA6;1-(4-(8-amino-3-(tert-butyl)imidazo[1,5-a]pyrazin-1-yl)naphthalen-1-yl)-3-(3-(trifluoromethyl)phenyl)urea;1-(4-(8-Amino-3-tert-butylimidazo[1,5-a]pyrazin-1-yl)naphthalen-1-yl)-3-(3-(trifluoromethyl)phenyl)urea;1-[4-(8-amino-3-tert-butylimidazo[1,5-a |
| 分子量: | 518.53 |
| 分子式: | C₂₈H₂₅F₃N₆O |
| SMILES: | O=C(NC1=CC=CC(C(F)(F)F)=C1)NC2=C3C=CC=CC3=C(C4=C5C(N)=NC=CN5C(C(C)(C)C)=N4)C=C2 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | KIRA6，小分子IRE1αRNase 激酶抑制剂，IC50值为0.6 µM。 KIRA6 可以触发细胞凋亡 (apoptotic) 反应。 |
| IC50和靶点: | |
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| Solvent & Solubility: |
Ghosh, R., Likun, W., Wang, E.S., et al.Allosteric inhibition of the IRE1α RNase preserves cell viability and function during endoplasmic reticulum stressCell158(3),534-548(2014)
Cosgrove, S.B., Wren, J.A., Cleaver, D.M., et al.Efficacy and safety of oclacitinib for the control of pruritus and associated skin lesions in dogs with canine allergic dermatitisVet. Dermatol.24(5),(2013)
