STF-083010
Cat. No.：YN290374
CAS No. ：307543-71-1
| 产品名称: | STF-083010 |
| CAS No.: | 307543-71-1 |
| Chemical Name: | N-[(2-hydroxy-naphthalenyl)methylene]-2-thiophenesulfonamide |
| Synonyms: | STF083010 |
| 分子量: | 317.38 |
| 分子式: | C₁₅H₁₁NO₃S₂ |
| SMILES: | O=S(C1=CC=CS1)(/N=C/C2=C3C=CC=CC3=CC=C2O)=O |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | STF-083010 是一种IRE1α特异性抑制剂。在内质网应激后，STF-083010 抑制 Ire1 内切核酸酶活性，而不影响其激酶活性。 |
| IC50和靶点: | |
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Papandreou, I., Denko, N.C., Olson, M., et al.Identification of an Ire1 alpha endonuclease specific inhibitor with cytotoxic activity against human multiple myelomaBlood117(4),1311-1314(2011)
Chien, W., Ding, L.W., Sun, Q.Y., et al.Selective inhibition of unfolded protein response induces apoptosis in pancreatic cancer cellsOncotarget5(13),4881-4894(2014)
