APY29
Cat. No.：YN290419
CAS No. ：1216665-49-4
| 产品名称: | APY29 |
| CAS No.: | 1216665-49-4 |
| Chemical Name: | N2-1H-benzimidazol-6-yl-N4-(5-cyclopropyl-1H-pyrazol-3-yl)-2,4-pyrimidinediamine |
| Synonyms: | APY29;N2-1H-benzimidazol-6-yl-N4-(5-cyclopropyl-1H-pyrazol-3-yl)-2,4-Pyrimidinediamine;APY-29;APY 29;N~2~-1h-Benzimidazol-5-Yl-N~4~-(3-Cyclopropyl-1h-Pyrazol-5-Yl)pyrimidine-2,4-Diamine;2,4-Pyrimidinediamine, N2-1H-benzimidazol-6-yl-N4-(5-cyclopropyl-1H-p |
| 分子量: | 332.36 |
| 分子式: | C₁₇H₁₆N₈ |
| SMILES: | C1(NC2=CC=C3N=CNC3=C2)=NC=CC(NC4=NNC(C5CC5)=C4)=N1 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | APY29 是 ATP 竞争性抑制剂，一种特异性的IRE1α别构调节剂，通过结合到 ATP 结合口袋来抑制 IRE1α 的自主磷酸化，IC50值为 280 nM。APY29 也可以变构激活 IRE1α 相邻 RNase 域。 |
| IC50和靶点: | |
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| Solvent & Solubility: |
Wang, L., Perera, B.G., Hari, S.B., et al.Divergent allosteric control of the IRE1α endoribonuclease using kinase inhibitorsNat. Chem. Biol.8(12),982-989(2012)
