Ponesimod
Cat. No.：YN320293
CAS No. ：854107-55-4
| 产品名称: | Ponesimod |
| CAS No.: | 854107-55-4 |
| Chemical Name: | (2Z)-5Z-[[3-chloro-4-[(2R)-2,3-dihydroxypropoxy]phenyl]methylene]-3-(2-methylphenyl)-2-(propylimino)-4-thiazolidinone |
| Synonyms: | ACT-128800 |
| 分子量: | 460.97 |
| 分子式: | C₂₃H₂₅ClN₂O₄S |
| SMILES: | O=C1N(C2=CC=CC=C2C)/C(S/C1=C\C3=CC=C(OC[C@H](O)CO)C(Cl)=C3)=N/CCC |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Ponesimod (ACT-128800) 是一种有效的，具有选择性和口服活性的S1P1的激动剂，在放射性配体结合试验中的IC50值为 6 nM。Ponesimod 可高效激活 S1P1介导的信号转导 (EC50=5.7 nM)。Ponesimod 可以预防淋巴细胞介导的组织炎症。 |
| IC50和靶点: | [{name:"S1PR1:6 nM (IC50)"},{name: "S1PR5:142 nM (IC50)"},{name: "S1PR4:1956 nM (IC50)"},{name: "S1PR3:2068 nM (IC50)"}] |
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Bolli, M.H., Abele, S., Binkert, C., et al.2-Imino-thiazolidin-4-one derivatives as potent, orally active S1P1 receptor agonistsJ. Med. Chem.53(10),4198-4211(2010)
Piali, L., Froidevaux, S., Hess, P., et al.The selective sphingosine 1-phosphate receptor 1 agonist ponesimod protects against lymphocyte-mediated tissue inflammationJ. Pharmacol. Exp. Ther.337(2),547-556(2011)
