AM966
Cat. No.：YN320955
CAS No. ：1228690-19-4
| 产品名称: | AM966 |
| CAS No.: | 1228690-19-4 |
| Chemical Name: | 4'-[4-[[[(1R)-1-(2-chlorophenyl)ethoxy]carbonyl]amino]-3-methyl-5-isoxazolyl]-[1,1'-biphenyl]-4-acetic acid |
| Synonyms: | 4'-[4-[[[(1R)-1-(2-氯苯基)乙氧基]羰基]氨基]-3-甲基-5-异恶唑基]-联苯-4-乙酸 |
| 分子量: | 490.93 |
| 分子式: | C₂₇H₂₃ClN₂O₅ |
| SMILES: | O=C(O)CC1=CC=C(C2=CC=C(C3=C(NC(O[C@@H](C4=CC=CC=C4Cl)C)=O)C(C)=NO3)C=C2)C=C1 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | AM966 是一种高亲和性的选择性LPA1-拮抗剂，抑制LPA-刺激的细胞内钙释放，IC50为 17 nM。 |
| IC50和靶点: | |
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| Solvent & Solubility: |
Swaney, J.S., Chapman, C., Correa, L.D., et al.A novel, orally active LPA1 receptor antagonist inhibits lung fibrosis in the mouse bleomycin modelBr. J. Pharmacol.160(7),1699-1713(2010)
Olianas, M.C., Dedoni, S., and Onali, P.Antidepressants activate the lysophosphatidic acid receptor LPA1 to induce insulin-like growth factor-I receptor transactivation, stimulation of ERK1/2 signaling and cell proliferation in CHO-K1 fibroblastsBiochem. Pharmacol.95(4),311-323(2015)
Cai, J., Wei, J., Li, S., et al.AM966, an antagonist of lysophosphatidic acid Receptor 1, increases lung microvascular endothelial permeability through activation of Rho signaling pathway and phosphorylation of VE-cadherinMediators Inflamm.2017,6893560(2017)
