Ceranib-2
Cat. No.：YN320493
CAS No. ：1402830-75-4
| 产品名称: | Ceranib-2 |
| CAS No.: | 1402830-75-4 |
| Chemical Name: | 3-[3-(4-methoxyphenyl)-1-oxo-2-propen-1-yl]-4-phenyl-2(1H)-quinolinone |
| Synonyms: | 3-[(E)-3-(4-hydroxyphenyl)prop-2-enoyl]-4-phenyl-1H-quinolin-2-one |
| 分子量: | 381.42 |
| 分子式: | C₂₅H₁₉NO₃ |
| SMILES: | O=C1NC(C=CC=C2)=C2C(C3=CC=CC=C3)=C1C(/C=C/C4=CC=C(C=C4)OC)=O |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Ceranib-2 是一种有效的非脂质神经酰胺酶 (ceramidase) 抑制剂，可在 SKOV3 细胞中抑制细胞神经酰胺酶活性，IC50为 28 μM。Ceranib-2 可诱导多种神经酰胺物质的积累，降低鞘氨醇和鞘氨醇1-磷酸 (S1P) 的水平，并诱导细胞凋亡 (apoptosis)。抗癌活性。 |
| IC50和靶点: | |
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| Clinical Trial: | |
| Solvent & Solubility: |
Draper, J.M., Xia, Z., Smith, R.A., et al.Discovery and evaluation of inhibitors of human ceramidaseMol. Cancer Ther.,1-27(2011)
