AM095 free acid
Cat. No.：YN321053
CAS No. ：1228690-36-5
| 产品名称: | AM095 free acid |
| CAS No.: | 1228690-36-5 |
| Chemical Name: | 4'-[3-methyl-4-[[[(1R)-1-phenylethoxy]carbonyl]amino]-5-isoxazolyl]-[1,1'-biphenyl]-4-acetic acid |
| Synonyms: | [4'-[3-甲基-4-[[[((R)-1-苯基乙基)氧基]羰基]氨基]异恶唑-5-基]联苯-4-基]乙酸 |
| 分子量: | 456.49 |
| 分子式: | C₂₇H₂₄N₂O₅ |
| SMILES: | O=C(O)CC1=CC=C(C2=CC=C(C3=C(NC(O[C@@H](C4=CC=CC=C4)C)=O)C(C)=NO3)C=C2)C=C1 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | AM095 free acid 是一种有效的LPA1受体拮抗剂，对重组人和小鼠 LPA1 的IC50值分别为 0.98 和 0.73 μM。 |
| IC50和靶点: | |
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| Solvent & Solubility: |
Castelino, F.V., Seiders, J., Bain, G., et al.Genetic deletion or pharmacologic antagonism of LPA1 ameliorates dermal fibrosis in a scleroderma mouse modelArthritis Rheum.63(5),1405-1415(2011)
Swaney, J.S., Chapman, C., Correa, L.D., et al.Pharmacokinetic and pharmacodynamic characterization of an oral lysophosphatidic acid type 1 receptor-selective antagonistJ. Pharmacol. Exp. Ther.336(3),693-700(2011)
