VH-298
Cat. No.：YN430001
CAS No. ：2097381-85-4
规格
价格(RMB)
库存
| 产品名称: | VH-298 |
| CAS No.: | 2097381-85-4 |
| Chemical Name: | (2S,4R)-1-((S)-2-(1-cyanocyclopropane-1-carboxamido)-3,3-dimethylbutanoyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide |
| Synonyms: | VH298;VH298 |
| 分子量: | 523.65 |
| 分子式: | C₂₇H₃₃N₅O₄S |
| SMILES: | O=C([C@H]1N(C([C@H](C(C)(C)C)NC(C2(CC2)C#N)=O)=O)C[C@H](O)C1)NCC3=CC=C(C4=C(C)N=CS4)C=C3 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | VH-298是高效的VHL:HIF-α相互作用抑制剂，Kd值为80-90 nM。 VH-298可用于PROTAC技术中。 |
| IC50和靶点: | |
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| Clinical Trial: | |
| Solvent & Solubility: |
Frost, J.M., Galdeano, C., Soares, P., et al.Potent and selective chemical probe of hypoxic signalling downstream of HIF-α hydroxylation via VHL inhibitionNat. Commun.7,13312(2016)
