Thalidomide 4-fluoride
Cat. No.：YN430370
CAS No. ：835616-60-9
规格
价格(RMB)
库存
| 产品名称: | Thalidomide 4-fluoride |
| CAS No.: | 835616-60-9 |
| Chemical Name: | 2-(2,6-dioxo-3-piperidinyl)-4-fluoro-1H-isoindole-1,3(2H)-dione |
| Synonyms: | Cereblon ligand 4; E3 ligase Ligand 4 |
| 分子量: | 276.22 |
| 分子式: | C₁₃H₉FN₂O₄ |
| SMILES: | O=C1N(C(CC2)C(NC2=O)=O)C(C3=C1C=CC=C3F)=O |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Thalidomide 4-fluoride (Cereblon ligand 4) 是一种基于 Thalidomide 的，可募集 CRBN 蛋白的 Cereblon 配体。Thalidomide 4-fluoride (Cereblon ligand 4) 可通过 linker 与 IRAK4 靶蛋白配体连接，形成 PROTAC IRAK4 degrader-1 (HY-129966)。 |
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Steinebach, C., Lindner, S., Udeshi, N.D., et al.Homo-PROTACs for the chemical knockdown of cereblonACS Chem. Biol.13(9),2771-2782(2018)
Yang, K., Song, Y., Xie, H., et al.Development of the first small molecule histone deacetylase 6 (HDAC6) degradersBioorg. Med. Chem. Lett.28(14),2493-2497(2018)
Powell, C.E., Gao, Y., Tan, L., et al.Chemically induced degradation of anaplastic lymphoma kinase (ALK)J. Med. Chem.61(9),4249-4255(2018)
