Thalidomide-O-COOH
Cat. No.：YN430009
CAS No. ：1061605-21-7
规格
价格(RMB)
库存
| 产品名称: | Thalidomide-O-COOH |
| CAS No.: | 1061605-21-7 |
| Chemical Name: | 2-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]oxy]-acetic acid |
| Synonyms: | Cereblon ligand 3; E3 ligase Ligand 3 |
| 分子量: | 332.26 |
| 分子式: | C₁₅H₁₂N₂O₇ |
| SMILES: | O=C(N(C(CCC1=O)C(N1)=O)C2=O)C(C2=CC=C3)=C3OCC(O)=O |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Thalidomide-O-COOH (Cereblon ligand 3) 是一种基于 Thalidomide 的，可募集 CRBN 蛋白的 Cereblon 配体。Thalidomide-O-COOH (Cereblon ligand 3) 可通过 linker 与靶蛋白配体连接，形成 PROTAC 分子。 |
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| Solvent & Solubility: |
Lohbeck, J., and Miller, A.K.Practical synthesis of a phthalimide-based Cereblon ligand to enable PROTAC developmentBioorg. Med. Chem. Lett.26(21),5260-5262(2016)
