Lenalidomide
Cat. No.：YN430390
CAS No. ：191732-72-6
规格
价格(RMB)
库存
| 产品名称: | Lenalidomide |
| CAS No.: | 191732-72-6 |
| Chemical Name: | 3-(4-amino-1,3-dihydro-1-oxo-2H-isoindol-2-yl)-2,6-piperidinedione |
| Synonyms: | 来那度胺; CC-5013 |
| 分子量: | 259.26 |
| 分子式: | C₁₃H₁₃N₃O₃ |
| SMILES: | O=C1C2=CC=CC(N)=C2CN1C(C(N3)=O)CCC3=O |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Lenalidomide (CC-5013) 是 Thalidomide 的衍生物，也是一种具有口服活性免疫调节剂。Lenalidomide (CC-5013) 是一种泛素 E3 连接酶 cereblon (CRBN) 的配体，可通过 CRBN-CRL4 泛素连接酶对两种淋巴转录因子 IKZF1 和 IKZF3 进行选择性泛素化和降解。Lenalidomide (CC-5013) 特别地抑制成熟 B 细胞淋巴瘤 (包括多发性骨髓瘤) 的生长，并诱导 T 细胞释放白细胞介素-2 (IL-2)。 |
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Muller, G.W., Chen, R., Huang, S.Y., et al.Amino-substituted thalidomide analogs: Potent inhibitors of TNF-α productionBioorg. Med. Chem. Lett.9(11),1625-1630(1999)
Krönke, J., Udeshi, N.D., Narla, A., et al.Lenalidomide causes selective degradation of IKZF1 and IKZF3 in multiple myeloma cellsScience343(6168),301-305(2014)
Dredge, K., Horsfall, R., Robinson, S.P., et al.Orally administered lenalidomide (CC-5013) is anti-angiogenic in vivo and inhibits endothelial cell migration and Akt phosphorylation in vitroMicrovasc. Res.69(1-2),56-63(2005)
