Thalidomide-4-OH
Cat. No.：YN430008
CAS No. ：5054-59-1
规格
价格(RMB)
库存
| 产品名称: | Thalidomide-4-OH |
| CAS No.: | 5054-59-1 |
| Chemical Name: | 2-(2,6-dioxo-3-piperidinyl)-4-hydroxy-1H-isoindole-1,3(2H)-dione |
| Synonyms: | Cereblon ligand 2; E3 ligase Ligand 2 |
| 分子量: | 274.23 |
| 分子式: | C₁₃H₁₀N₂O₅ |
| SMILES: | OC1=CC=CC(C(N2C3C(NC(CC3)=O)=O)=O)=C1C2=O |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Thalidomide-4-OH (Cereblon ligand 2) 是一种基于 Thalidomide 的，可募集 CRBN 蛋白的 Cereblon 配体。Thalidomide-4-OH (Cereblon ligand 2) 可通过 linker 与靶蛋白配体连接，形成 PROTAC 分子。 |
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Marks, M.G., Shi, J., Fry, M.O., et al.Effects of putative hydroxylated thalidomide metabolites on blood vessel density in the chorioallantoic membrane (CAM) assay and on tumor and endothelial cell proliferationBiol. Pharm. Bull.25(5),597-604(2002)
Robb, C.M., Contreras, J.I., Kour, S., et al.Chemically induced degradation of CDK9 by a proteolysis targeting chimera (PROTAC)Chem. Commun. (Camb.)53(54),7577-7580(2017)
Nakamura, T., Noguchi, T., Kobayashi, H., et al.Mono- and dihydroxylated metabolites of thalidomide: Synthesis and TNF-α production-inhibitory activityChem. Pharm. Bull. (Tokyo)54(12),1709-1714(2006)
