(RS)-(Tetrazol-5-yl)glycine
Cat. No.：YN360061
CAS No. ：138199-51-6
| 产品名称: | (RS)-(Tetrazol-5-yl)glycine |
| CAS No.: | 138199-51-6 |
| Chemical Name: | α-amino-2H-tetrazole-5-acetic acid |
| Synonyms: | D,L-(tetrazol-5-yl)glycine; LY 285265 |
| 分子量: | 143.10 |
| 分子式: | C₃H₅N₅O₂ |
| SMILES: | O=C(O)C(N)C1=NNN=N1 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | (RS)-(Tetrazol-5-yl)glycine (D,L-(tetrazol-5-yl)glycine) 是一种高效且选择性的 N-甲基-D-天冬氨酸 (NMDA) 受体激动剂。(RS)-(Tetrazol-5-yl)glycine 对 GluN1/GluN2D 和 GluN1/GluN2A 的EC50分别为 99 nM，1.7 μM。(RS)-(Tetrazol-5-yl)glycine 诱导小鼠癫痫发作反应和 Fos。 |
| IC50和靶点: | |
| In Vitro: | |
| In Vivo: | |
| Clinical Trial: | |
| Solvent & Solubility: |
Schoepp, D.D., Smith, C.L., Lodge, D., et al.D,L-(Tetrazol-5-yl) glycine: A novel and highly potent NMDA receptor agonistEur. J. Pharmacol.203(2),237-243(1991)
Schoepp, D.D., Lunn, W.H.W., C.R., S., et al.The NMDA receptor agonist DL-(tetrazol-5-yl)glycine is a highly potent excitotoxinEur. J. Pharmacol.270(1),67-72(1994)
An, Y., Belevych, N., Wang, Y., et al.Neuronal and nonneuronal COX-2 expression confers neurotoxic and neuroprotective phenotypes in response to excitotoxin challengeJ. Neurosci. Res.92(4),486-495(2014)
