L-701324
Cat. No.：YN360657
CAS No. ：142326-59-8
规格
价格(RMB)
库存
| 产品名称: | L-701324 |
| CAS No.: | 142326-59-8 |
| Chemical Name: | 7-chloro-4-hydroxy-3-(3-phenoxyphenyl)-2(1H)-quinolinone |
| Synonyms: | L701324,7-氯-4-羟基-3-(3-苯氧基)苯基-2(1H)-喹啉 |
| 分子量: | 363.79 |
| 分子式: | C₂₁H₁₄ClNO₃ |
| SMILES: | O=C1NC2=C(C=CC(Cl)=C2)C(O)=C1C3=CC=CC(OC4=CC=CC=C4)=C3 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | L-701324是一种具有口服活性的, 长效抗惊厥剂, 对NMDA受体的甘氨酸位点具有高亲和力和选择性。 |
| IC50和靶点: | |
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Priestley, T., Laughton, P., Macaulay, A.J., et al.Electrophysiological characterisation of the antagonist properties of two novel NMDA receptor glycine site antagonists, L-695,902 and L-701,324Neuropharmacology35(11),1573-1581(1996)
Bristow, L.J., Hutson, P.H., Kulagowski, J.J., et al.Anticonvulsant and behavioral profile of L-701,324, a potent, orally active antagonist at the glycine modulatory site on the N-methyl-D-aspartate receptor complexJ. Pharmacol. Exp. Ther.279(2),492-501(1996)
Kotlinska, J., and Liljequist, S.Oral administration of glycine and polyamine receptor antagonists blocks ethanol withdrawal seizuresPsychopharmacology (Berl)127(3),238-244(1996)
Bristow, L.J., Flatman, K.L., Hutson, P.H., et al.The atypical neuroleptic profile of the glycine/N-methyl-D-aspartate receptor antagonist, L-701,324, in rodentsJ. Pharmacol. Exp. Ther.277(2),578-585(1996)
