Felbamate
Cat. No.：YN360745
CAS No. ：25451-15-4
| 产品名称: | Felbamate |
| CAS No.: | 25451-15-4 |
| Chemical Name: | 2-phenyl-1,3-propanediol 1,3-dicarbamate |
| Synonyms: | 非尔氨酯; W-554; ADD-03055 |
| 分子量: | 238.24 |
| 分子式: | C₁₁H₁₄N₂O₄ |
| SMILES: | NC(OCC(C1=CC=CC=C1)COC(N)=O)=O |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Felbamate (W-554) 是非镇静性抗痉挛剂，活性与NMDA受体相关。 |
| IC50和靶点: | |
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Kuo, C.-C., Lin, B.-J., Chang, H.-R., et al.Use-dependent inhibition of the N-methyl-D-aspartate currents by felbamate: a gating modifier with selective binding to the desensitized channelsMol. Pharmacol.65(2),370-380(2004)
Simeone, T.A., Otto, J.F., Wilcox, K.S., et al.Felbamate is a subunit selective modulator of recombinant γ-aminobutyric acid type A receptors expressed in Xenopus oocytesEur. J. Pharmacol.552(1-3),31-35(2006)
Domenici, M.R., Sagratella, S., Ongini, E., et al.Felbamate displays in vitro antiepileptic effects as a broad spectrum excitatory amino acid receptor antagonistEur. J. Pharmacol.271(2-3),259-263(1994)
Swinyard, E.A., Sofia, R.D., and Kupferberg, H.J.Comparative anticonvulsant activity and neurotoxicity of felbamate and four prototype antiepileptic drugs in mice and ratsEpilepsia27(1),27-34(1986)
