N-Methylcytisine
Cat. No.：YN360927
CAS No. ：486-86-2
| 产品名称: | N-Methylcytisine |
| CAS No.: | 486-86-2 |
| Chemical Name: | (1R,5S)-1,2,3,4,5,6-hexahydro-3-methyl-1,5-methano-8H-pyrido[1,2-a][1,5]diazocin-8-one |
| Synonyms: | Caulophylline |
| 分子量: | 204.27 |
| 分子式: | C₁₂H₁₆N₂O |
| SMILES: | O=C1C=CC=C2N1C[C@]3([H])CN(C)C[C@@]2([H])C3 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | N-Methylcytisine (Caulophylline) 是一种三环喹啉类生物碱，具有降血糖、镇痛、抗炎活性。N-Methylcytisine 是中枢神经系统中乙酰胆碱烟碱受体的选择性配体，对鱿鱼视神经节中的烟碱乙酰胆碱受体具有很高的亲和力 (Kd: 50 nM)。 |
| IC50和靶点: | |
| In Vitro: | |
| In Vivo: | |
| Clinical Trial: | |
| Solvent & Solubility: |
Schmeller, T., Sauerwein, M., Sporer, F., et al.Binding of quinolizidine alkaloids to nicotinic and muscarinic acetylcholine receptorsJ. Nat. Prod.57(9),1316-1319(1994)
Slater, Y.E., Houlihan, L.M., Maskell, P.D., et al.Halogenated cytisine derivatives as agonists at human neuronal nicotinic acetylcholine receptor subtypesNeuropharmacology44(4),503-515(2003)
Matsuda, K., Yamada, K., Kimura, M., et al.Nematicidal activity of matrine and its derivatives against pine wood nematodesJ. Agric. Food Chem.39(1),189-191(1991)
Li, J.-C., Dai, W.-F., Liu, D., et al.Quinolizidine alkaloids from Sophora alopecuroides with anti-inflammatory and anti-tumor propertiesBioorg. Chem.110,104781(2021)
Gao, L., Wang, K.-x., Zhou, Y.-z., et al.Uncovering the anticancer mechanism of Compound Kushen Injection against HCC by integrating quantitative analysis, network analysis and experimental validationSci. Rep.8(1),624(2018)
