COG 133
Cat. No.：YN361030
| 产品名称: | COG 133 |
| CAS No.: | 514200-66-9 |
| Chemical Name: | N-acetyl-L-leucyl-L-arginyl-L-valyl-L-arginyl-L-leucyl-L-alanyl-L-seryl-L-histidyl-L-leucyl-L-arginyl-L-lysyl-L-leucyl-L-arginyl-L-lysyl-L-arginyl-L-leucyl-L-leucinamide, trifuoroacetate salt |
| Synonyms: | Ac-LRVRLASHLRKLRKRLL-NH2 |
| 分子量: | 2169.71 |
| 分子式: | C₉₇H₁₈₁N₃₇O₁₉ |
| SMILES: | [Ac-LRVRLASHLRKLRKRLL-NH2] |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | COG 133 是载脂蛋白 E (Apolipoprotein E, APOE) 肽的片段。COG 133 与 ApoE 全息蛋白竞争结合 LDL 受体，具有有效的抗炎和神经保护作用。COG 133 也是nAChR拮抗剂，IC50为 445 nM。 |
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Laskowitz, D.T., Thekdi, A.D., Thekdi, S.D., et al.Downregulation of microglial activation by apolipoprotein E and ApoE-mimetic peptidesExp. Neurol.167(1),74-85(2001)
Klein, R.C., and Yakel, J.L.Inhibition of nicotinic acetylcholine receptors by apolipoprotein E-derived peptides in rat hippocampal slicesNeuroscience127(3),563-567(2004)
Lynch, J.R., Tang, W., Wang, H., et al.APOE genotype and an ApoE-mimetic peptide modify the systemic and central nervous system inflammatory responseJ. Biol. Chem.278(49),48529-48533(2003)
Lynch, J.R., Wang, H., Mace, B., et al.A novel therapeutic derived from apolipoprotein E reduces brain inflammation and improves outcome after closed head injuryExp. Neurol.192(1),109-116(2005)
Li, F.-Q., Sempowski, G.D., McKenna, S.E., et al.Apolipoprotein E-derived peptides ameliorate clinical disability and inflammatory infiltrates into the spinal cord in a murine model of multiple sclerosisPharmacol. Exp. Ther.318(3),956-965(2006)
