Neflamapimod
Cat. No.：YN350028
CAS No. ：209410-46-8
| 产品名称: | Neflamapimod |
| CAS No.: | 209410-46-8 |
| Chemical Name: | 5-(2,6-dichlorophenyl)-2-[(2,4-difluorophenyl)thio]-6H-pyrimido[1,6-b]pyridazin-6-one |
| Synonyms: | VX-745 |
| 分子量: | 436.26 |
| 分子式: | C₁₉H₉Cl₂F₂N₃OS |
| SMILES: | O=C1N=CN(C(C=C2)=C1C3=C(Cl)C=CC=C3Cl)N=C2SC4=CC=C(F)C=C4F |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Neflamapimod (VX-745) 是有效的，可穿过血脑屏障的，高选择性的p38α抑制剂，对 p38α 的IC50值为 10 nM，p38β 的IC50值为 220 nM。Neflamapimod (VX-745) 具有抗炎活性。 |
| IC50和靶点: | [{name:"p38α:10 nM (IC50)"},{name: "p38β:220 nM (IC50)"}] |
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| Solvent & Solubility: |
Duffy, J.P., Harrington, E.M., Salituro, F.G., et al.The discovery of VX-745: A novel and selective p38α kinase inhibitorACS Med. Chem. Lett.2(10),758-763(2011)
