Pexmetinib
Cat. No.：YN350180
CAS No. ：945614-12-0
| 产品名称: | Pexmetinib |
| CAS No.: | 945614-12-0 |
| Chemical Name: | N-[3-(1,1-dimethylethyl)-1-(4-methylphenyl)-1H-pyrazol-5-yl]-N'-[[5-fluoro-2-[[1-(2-hydroxyethyl)-1H-indazol-5-yl]oxy]phenyl]methyl]-urea |
| Synonyms: | ARRY-614 |
| 分子量: | 556.63 |
| 分子式: | C₃₁H₃₃FN₆O₃ |
| SMILES: | O=C(NCC1=CC(F)=CC=C1OC2=CC3=C(N(CCO)N=C3)C=C2)NC4=CC(C(C)(C)C)=NN4C5=CC=C(C)C=C5 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Pexmetinib 是一种有效的Tie-2和p38 MAPK双重抑制剂，对 Tie-2，p38α 和 p38β 的IC50值分别为 1 nM，35 nM 和 26 nM，可用于急性骨髓性白血病的研究。 |
| IC50和靶点: | |
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| Solvent & Solubility: |
Bachegowda, L., Morrone, K., Winski, S.L., et al.Pexmetinib: A novel dual inhibitor of Tie-2 and p38 MAPK with efficacy in preclinical models of myelodysplastic syndromes and acute myeloid leukemiaCancer Res.76(16),4841-4849(2016)
