SD-169
Cat. No.：YN350274
CAS No. ：1670-87-7
规格
价格(RMB)
库存
| 产品名称: | SD-169 |
| CAS No.: | 1670-87-7 |
| Chemical Name: | 1H-indole-5-carboxamide |
| Synonyms: | SD 169,1H-吲哚-5-甲酰胺 |
| 分子量: | 160.18 |
| 分子式: | C₉H₈N₂O |
| SMILES: | O=C(C1=CC2=C(NC=C2)C=C1)N |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | SD-169 是一种有口服活性的 ATP 竞争性MAPK p38α抑制剂，其IC50值为 3.2 nM。SD-169 对p38β MAPK也有较弱的抑制作用，其IC50值为 122 nM。SD-169 通过抑制 T 细胞的浸润和活化阻止糖尿病的发展。 |
| IC50和靶点: | [{name:"p38α MAPK:3.2 nM (IC50)"},{name: "p38β MAPK:122 nM (IC50)"}] |
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| Solvent & Solubility: |
Medicherla, S., Protter, A.A., Ma, J.Y., et al.Preventive and therapeutic potential of p38α-selective mitogen-activated protein kinase inhibitor in nonobese diabetic mice with type 1 diabetesJ. Pharmacol. Exp. Ther.318(1),99-107(2006)
Myers, R.R., Sekiguchi, Y., Kikuchi, S., et al.Inhibition of p38 MAP kinase activity enhances axonal regenerationExp. Neurol.184(2),606-614(2003)
