RWJ-67657
Cat. No.：YN350162
CAS No. ：215303-72-3
| 产品名称: | RWJ-67657 |
| CAS No.: | 215303-72-3 |
| Chemical Name: | 4-[4-(4-fluorophenyl)-1-(3-phenylpropyl)-5-(4-pyridinyl)-1H-imidazol-2-yl]-3-butyn-1-ol |
| Synonyms: | JNJ 3026582 |
| 分子量: | 425.50 |
| 分子式: | C₂₇H₂₄FN₃O |
| SMILES: | OCCC#CC1=NC(C2=CC=C(F)C=C2)=C(C3=CC=NC=C3)N1CCCC4=CC=CC=C4 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | RWJ-67657 (JNJ 3026582) 是一种具有口服活性的选择性p38α和p38β抑制剂，IC50分别为 1 和 11 μM。RWJ-67657 对 p38γ 和 p38δ 无活性，是心脏保护剂，具有抗炎和抗肿瘤活性。 |
| IC50和靶点: | [{name:"p38α:1 μM (IC50)"},{name: "p38β:11 μM (IC50)"}] |
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| Clinical Trial: | |
| Solvent & Solubility: |
Wadsworth, S.A., Cavender, D.E., Beers, S.A., et al.RWJ 67657, a potent, orally active inhibitor of p38 mitogen-activated protein kinaseJ. Pharmacol. Exp. Ther.291(2),680-687(1999)
Schafer, P.H., Wadsworth, S.A., Wang, L., et al.p38 α mitogen-activated protein kinase is activated by CD28-mediated signaling and is required for IL-4 production by human CD4+ CD45RO+ T cells and Th2 effector cellsJ. Immunol.162(12),7110-7119(2016)
Kompa, A.R., See, F., Lewis, D.A., et al.Long-term but not short-term p38 mitogen-activated protein kinase inhibition improves cardiac function and reduces cardiac remodeling post-myocardial infarctionJ. Pharmacol. Exp. Ther.325(3),741-750(2008)
Antoon, J.W., Nitzchke, A.M., Martin, E.C., et al.Inhibition of p38 mitogen-activated protein kinase alters microRNA expression and reverses epithelial-to-mesenchymal transitionInt. J. Oncol.42(4),1139-1150(2013)
Bai, Y.Y., Wang, L., Chang, D., et al.Synergistic effects of transplanted endothelial progenitor cells and RWJ 67657 in diabetic ischemic stroke modelsStroke46(7),1938-1946(2015)
