Acumapimod
Cat. No.：YN350179
CAS No. ：836683-15-9
规格
价格(RMB)
库存
| 产品名称: | Acumapimod |
| CAS No.: | 836683-15-9 |
| Chemical Name: | 3-[5-amino-4-(3-cyanobenzoyl)-1H-pyrazol-1-yl]-N-cyclopropyl-4-methyl-benzamide |
| Synonyms: | BCT-197 |
| 分子量: | 385.42 |
| 分子式: | C₂₂H₁₉N₅O₂ |
| SMILES: | O=C(NC1CC1)C2=CC=C(C)C(N3N=CC(C(C4=CC=CC(C#N)=C4)=O)=C3N)=C2 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Acumapimod (BCT197) 是口服活性的p38 MAP激酶抑制剂，对p38α的IC50值小于1 μM。 |
| IC50和靶点: | |
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| Solvent & Solubility: |
Fryszman, O.M., Lang, H., Lan, J., et al.5-membered heterocycle-based p38 kinase inhibitors,(2005)
Growcott, E.J., Bamba, D., Galarneau, J.R., et al.The effect of P38 MAP kinase inhibition in a mouse model of influenzaJ. Med. Microbiol.67(3),452-463(2018)
Parkin, J.M., and Hardaker, E.L.Effects of acumapimod (bct197), an oral p38 inhibitor, on tobacco smoke and lipopolysaccharide-induced lung inflammation in a corticosteroid-resistant rat modelAm. J. Respir. Crit. Care Med.195:A6305,(2017)
