PH-797804
Cat. No.：YN350036
CAS No. ：586379-66-0
| 产品名称: | PH-797804 |
| CAS No.: | 586379-66-0 |
| Chemical Name: | 3-[3-bromo-4-[(2,4-difluorophenyl)methoxy]-6-methyl-2-oxo-1(2H)-pyridinyl]-N,4-dimethyl-benzamide |
| Synonyms: | PH797804 |
| 分子量: | 477.30 |
| 分子式: | C₂₂H₁₉BrF₂N₂O₃ |
| SMILES: | O=C(C1=CC=C(C(N2C(C)=CC(OCC3=CC=C(C=C3F)F)=C(C2=O)Br)=C1)C)NC |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | PH-797804 是一种 ATP 竞争性的，选择性的p38α/p38β抑制剂，对 p38α 的IC50为 26 nM，Ki值为 5.8 nM；对 p38β 的Ki值为 40 nM，对 JNK2 没有抑制作用. |
| IC50和靶点: | |
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| Solvent & Solubility: |
Hope, H.R., Anderson, G.D., Burnette, B.L., et al.Anti-inflammatory properties of a novel N-phenyl pyridinone inhibitor of p38 mitogen-activated protein kinase: preclinical-to-clinical translationJ. Pharmacol. Exp. Ther.331(3),882-895(2009)
Goldstein, D.M., Kuglstatter, A., Lou, Y., et al.Selective p38α inhibitors clinically evaluated for the treatment of chronic inflammatory disordersJ. Med. Chem.53,2345-2353(2010)
