Sitaxsentan sodium
Cat. No.：YN320427
CAS No. ：210421-74-2
| 产品名称: | Sitaxsentan sodium |
| CAS No.: | 210421-74-2 |
| Chemical Name: | N-(4-chloro-3-methyl-5-isoxazolyl)-2-[2-(6-methyl-1,3-benzodioxol-5-yl)acetyl]-3-thiophenesulfonamide, monosodium salt |
| Synonyms: | IPI 1040 sodium; TBC11251 sodium |
| 分子量: | 476.89 |
| 分子式: | C₁₈H₁₄ClN₂NaO₆S₂ |
| SMILES: | O=S(C1=C(SC=C1)C(CC2=C(C=C3OCOC3=C2)C)=O)(N([Na])C4=C(C(C)=NO4)Cl)=O |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Sitaxsentan sodium (IPI 1040 sodium; TBC11251 sodium) 是一种有效的，选择性的endothelin A receptor拮抗剂。 |
| IC50和靶点: | |
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Wu, C., Chan, M.F., Stavros, F.L., et al.Discovery of TBC11251, a potent, long acting, orally active endothelin receptor-A selective antagonistJ. Med. Chem.40(11),1690-1697(1997)
Duthie, K.M., Hadoke, P.W., Kirkby, N.S., et al.Selective endothelin A receptor antagonism with sitaxentan reduces neointimal lesion size in a mouse model of intraluminal injuryBr. J. Pharmacol.172(11),2827-2837(2015)
Manitsopoulos, N., Nikitopoulos, I., Maniatis, N.A., et al.Highly selective endothelin-1 receptor A inhibition prevents bleomycin-induced pulmonary inflammation and fibrosis in miceRespiration95(2),122-136(2018)
