Bosentan
Cat. No.：YN321323
CAS No. ：147536-97-8
| 产品名称: | Bosentan |
| CAS No.: | 147536-97-8 |
| Chemical Name: | 4-(1,1-dimethylethyl)-N-[6-(2-hydroxyethoxy)-5-(2-methoxyphenoxy)[2,2'-bipyrimidin]-4-yl]-benzenesulfonamide |
| Synonyms: | 波生坦 |
| 分子量: | 551.61 |
| 分子式: | C₂₇H₂₉N₅O₆S |
| SMILES: | O=S(NC1=NC(C2=NC=CC=N2)=NC(OCCO)=C1OC3=CC=CC=C3OC)(C4=CC=C(C(C)(C)C)C=C4)=O |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Bosentan 是一种有效的endothelin-1 (ET)拮抗剂，在人的 SMC 细胞中，作用于 ETA和 ETB受体，Ki值分别为 4.7 nM 和 95 nM。 |
| IC50和靶点: | |
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| Solvent & Solubility: |
Jae, H.S., Winn, M., Dixon, D.B., et al.Pyrrolidine-3-carboxylic acids as endothelin antagonists. 2. Sulfonamide-based ETA/ETB mixed antagonistsJ. Med. Chem.40(20),3217-3227(1997)
Wu, C., Decker, E.R., Blok, H., et al.Discovery, modeling, and human pharmacokinetics of N-(2-acetyl-4,6-dimethylphenyl)-3-(3,4-dimethylisoxazol-5-ylsulfamoyl)-thiophene-2-carboxamide (TBC3711), a second generation, ETA selective, and orally bioavailable endothelin antagonistJ. Med. Chem.47(8),1969-1986(2004)
