Bosentan (hydrate)
Cat. No.：YN321324
CAS No. ：157212-55-0
| 产品名称: | Bosentan (hydrate) |
| CAS No.: | 157212-55-0 |
| Chemical Name: | 4-(1,1-Dimethylethyl)-N-[6-(2-hydroxyethoxy)-5-(2-methoxyphenoxy)[2,2'-bipyrimidin]-4-yl]benzenesulfonamide Hydrate (1:1); |
| Synonyms: | 波生坦水合物 |
| 分子量: | 569.63 |
| 分子式: | C₂₇H₃₁N₅O₇S |
| SMILES: | O=S(NC1=NC(C2=NC=CC=N2)=NC(OCCO)=C1OC3=CC=CC=C3OC)(C4=CC=C(C(C)(C)C)C=C4)=O.O |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Bosentan hydrate 是一种竞争性的endothelin-1 (ET)拮抗剂，在人SMC中，作用于 ETA和 ETB受体，Ki分别为 4.7 nM 和 95 nM。 |
| IC50和靶点: | |
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| Solvent & Solubility: |
Clozel, M., et al.: J. Pharmacol. Exp. Ther., 270, 228 (1994), Gutsch, G., et al.: Cardiovasc. Drugs Ther., 10, 717 (1996), Weber, C., et al.: Clin Pharmacol. Ther., 60, 124 (1996), Krum, H., et al.: N. Engl. J. Med., 338, 784 (1998)
