Atrasentan
Cat. No.：YN320974
| 产品名称: | Atrasentan |
| CAS No.: | 173937-91-2 |
| Chemical Name: | Altrasentan; (2R,3R,4S)-4-(1,3-Benzodioxol-5-yl)-1-[2-(dibutylamino)-2-oxoethyl]-2-(4-methoxyphenyl)pyrrolidine-3-carboxylic Acid; (2R,3R,4S)-4-(1,3-Benzodioxol-5-yl)-1-[2-(dibutylamino)-2-oxoethyl]-2-(4-methoxyphenyl)-3-pyrrolidinecarboxylic Acid; (+)-A |
| Synonyms: | ABT-627; (+)-A 127722; A-147627 |
| 分子量: | 542.69 |
| 分子式: | C₂₉H₃₈N₂O₆S |
| SMILES: | O=C([C@H]1[C@H](C2=CC=C(OC)C=C2)N(CC(N(CCCC)CCCC)=O)C[C@@H]1C3=CC=C(OCO4)C4=C3)O.[S].[R].[R] |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Atrasentan (ABT-627) 是一种有效的内皮素受体 (endothelin receptor) 拮抗剂，抑制 ETA的活性，IC50值为 0.0551 nM。 |
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Bax, W., et al.: Trends Pharmacol. Sci., 15, 379 (1994)
Winn, M., et al.: J. Med. Chem., 39, 1039 (1996)
Wu-Wong, J., et al.: J. Pharmacol. Exp. Ther., 281, 791 (1997)
