Ambrisentan
Cat. No.：YN320706
CAS No. ：177036-94-1
规格
价格(RMB)
库存
| 产品名称: | Ambrisentan |
| CAS No.: | 177036-94-1 |
| Chemical Name: | αS-[(4,6-dimethyl-2-pyrimidinyl)oxy]-β-methoxy-β-phenyl-benzenepropanoic acid |
| Synonyms: | 安倍生坦; BSF 208075; LU 208075 |
| 分子量: | 378.42 |
| 分子式: | C₂₂H₂₂N₂O₄ |
| SMILES: | O=C([C@H](C(OC)(C1=CC=CC=C1)C2=CC=CC=C2)OC3=NC(C)=CC(C)=N3)O |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Ambrisentan 是一种选择性的ET A型受体 (ETAR) 拮抗剂。 |
| IC50和靶点: | |
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Yokoyama, Y., Osano, A., Hyashi, H., et al.Endothelin-1 receptors in rat tissues: Characterization by bosentan, ambrisentan and CI-1020Biol. Pharm. Bull.37(3),461-465(2014)
Xia, J., Song, J., Zhen, L., et al.Synthesis and in vitro evaluation of ambrisentan analogues as potential endothelin receptor antagonistsBioorg. Med. Chem. Lett.21(13),3894-3897(2011)
Angus, J.A., Soeding, P.F., Hughes, R.J.A., et al.Functional estimation of endothelin-1 receptor antagonism by bosentan, macitentan and ambrisentan in human pulmonary and radial arteries in vitroEur. J. Pharmacol.804,111-116(2017)
Wagenaar, G.T., Laghmani, e.H., de Visser, Y.P., et al.Ambrisentan reduces pulmonary arterial hypertension but does not stimulate alveolar and vascular development in neonatal rats with hyperoxic lung injuryAm. J. Physiol. Lung Cell Mol. Physiol.304(4),L264-L275(2013)
