Macitentan
Cat. No.：YN320831
CAS No. ：441798-33-0
规格
价格(RMB)
库存
| 产品名称: | Macitentan |
| CAS No.: | 441798-33-0 |
| Chemical Name: | N-[5-(4-bromophenyl)-6-[2-[(5-bromo-2-pyrimidinyl)oxy]ethoxy]-4-pyrimidinyl]-N'-propyl-sulfamide |
| Synonyms: | 马西替坦; ACT-064992 |
| 分子量: | 588.27 |
| 分子式: | C₁₉H₂₀Br₂N₆O₄S |
| SMILES: | BrC1=CN=C(OCCOC2=C(C3=CC=C(Br)C=C3)C(NS(NCCC)(=O)=O)=NC=N2)N=C1 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Macitentan (ACT-064992) 是有口服活性，非多肽ETA和ETB(内皮素受体)双拮抗剂。Macitentan 有用于特发性肺纤维化和肺动脉高压的潜力。 |
| IC50和靶点: | |
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Iglarz, M., Binkert, C., Morrison, K., et al.Pharmacology of macitentan, an orally active tissue-targeting dual endothelin receptor antagonistJ. Pharmacol. Exp. Ther.327(3),736-745(2008)
Lefaucheur, C., Loupy, A., and Zeevi, A.Complement-binding anti-HLA antibodies and kidney transplantationN. Engl. J. Med.370(1),85-86(2014)
