PF-3845
Cat. No.：YN372201
CAS No. ：1196109-52-0
| 产品名称: | PF-3845 |
| CAS No.: | 1196109-52-0 |
| Chemical Name: | N-3-pyridinyl-4-[[3-[[5-(trifluoromethyl)-2-pyridinyl]oxy]phenyl]methyl]-1-piperidinecarboxamide |
| Synonyms: | PF3845, PF3845 |
| 分子量: | 456.46 |
| 分子式: | C₂₄H₂₃F₃N₄O₂ |
| SMILES: | O=C(N1CCC(CC2=CC=CC(OC3=NC=C(C=C3)C(F)(F)F)=C2)CC1)NC4=CN=CC=C4 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | PF-3845 是一种有效的，选择性的，不可逆和具有口服活性的脂肪酸酰胺水解酶 (FAAH) 抑制剂，Ki值为 0.23 µM。PF-3845 是将 FAAH 的丝氨酸亲核试剂氨基甲酸酯化的共价抑制剂。PF-3845 可以减少疼痛感，炎症和焦虑/抑郁，而对运动或认知没有实质性影响。 |
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| Solvent & Solubility: |
Ahn, K., Johnson, D.S., Mileni, M., et al.Discovery and characterization of a highly selective FAAH inhibitor that reduces inflammatory painChem. Biol.16(4),411-420(2009)
