JNJ-1661010
Cat. No.：YN373392
CAS No. ：681136-29-8
| 产品名称: | JNJ-1661010 |
| CAS No.: | 681136-29-8 |
| Chemical Name: | N-phenyl-4-(3-phenyl-1,2,4-thiadiazol-5-yl)-1-piperazinecarboxamide |
| Synonyms: | Takeda-25 |
| 分子量: | 365.45 |
| 分子式: | C₁₉H₁₉N₅OS |
| SMILES: | O=C(NC1=CC=CC=C1)N(CC2)CCN2C3=NC(C4=CC=CC=C4)=NS3 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | JNJ-1661010 (Takeda-25) 是一种有效的选择性脂肪酸酰胺水解酶 (FAAH) 抑制剂，对大鼠和人FAAH 的IC50分别为 34 和 33 nM。JNJ-1661010 可以穿透血脑屏障，用作广谱镇痛药。 |
| IC50和靶点: | |
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| Clinical Trial: | |
| Solvent & Solubility: |
Keith, J.M., Apodaca, R., Xiao, W., et al.Thiadiazolopiperazinyl ureas as inhibitors of fatty acid amide hydrolaseBioorg. Med. Chem. Lett.18(17),4838-4843(2008)
Palumbo-Zerr, K., Horn, A., Distler, A., et al.Inactivation of fatty acid amide hydrolase exacerbates experimental fibrosis by enhanced endocannabinoid-mediated activation of CB1Ann. Rheum. Dis.71,2051-2054(2012)
