CHIR-99021 monohydrochloride
Cat. No.:YN420030
产品名称: | CHIR-99021 monohydrochloride |
CAS No.: | 1797989-42-4 |
Chemical Name: | 6-[[2-[[4-(2,4-Dichlorophenyl)-5-(5-methyl-1H-imidazol-2-yl)-2-pyrimidinyl]amino]ethyl]amino]-3-pyridinecarbonitrile Hydrochloride; CHIR 911 Hydrochloride; CT 99021 Hydrochloride; CHIR99021 |
Synonyms: | CT99021 monohydrochloride |
分子量: | 501.80 |
分子式: | C₂₂H₁₉Cl₃N₈ |
SMILES: | N#CC1=CC=C(NCCNC2=NC=C(C3=NC=C(C)N3)C(C4=CC=C(Cl)C=C4Cl)=N2)N=C1.[H]Cl |
存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
运输: | Room temperature in continental US; may vary elsewhere. |
产品描述: | CHIR-99021 monohydrochloride (CT99021 monohydrochloride) 是一种有效的选择性GSK-3α/β抑制剂,IC50为 10 nM 和 6.7 nM。CHIR-99021 monohydrochloride 对GSK-3的选择性比 CDC2,ERK2 和其他蛋白激酶高 500 倍以上。CHIR-99021 monohydrochloride 还是一种有效的Wnt/β-catenin信号通路激活剂。CHIR-99021 monohydrochloride 可增 |
IC50和靶点: | [{name:"GSK-3β:6.7 nM (IC50)"},{name: "GSK-3α:10 nM (IC50)"},{name: "cdc2:8800 nM (IC50)"}] |
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