Tideglusib
Cat. No.：YN420195
CAS No. ：865854-05-3
规格
价格(RMB)
库存
| 产品名称: | Tideglusib |
| CAS No.: | 865854-05-3 |
| Chemical Name: | 2-(1-naphthalenyl)-4-(phenylmethyl)-1,2,4-thiadiazolidine-3,5-dione |
| Synonyms: | NP031112 |
| 分子量: | 334.39 |
| 分子式: | C₁₉H₁₄N₂O₂S |
| SMILES: | O=C(N(SC1=O)C2=C3C=CC=CC3=CC=C2)N1CC4=CC=CC=C4 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Tideglusib (NP031112) 是一种不可逆的GSK-3抑制剂，抑制GSK-3βWT和GSK-3βC199A的IC50分别为5 nM，60 nM。 |
| IC50和靶点: | [{name:"GSK-3β(WT):5 nM (IC50)"},{name: "GSK-3β(C199A):60 nM (IC50)"}] |
| In Vitro: | |
| In Vivo: | |
| Clinical Trial: | |
| Solvent & Solubility: |
Luna-Medina, R., Cortes-Canteli, M., Sanchez-Galiano, S., et al.NP031112, a thiadiazolidinone compound, prevents inflammation and neurodegeneration under excitotoxic conditions: Potential therapeutic role in brain disordersJ. Neurosci.27(21),5766-5776(2007)
Domínguez, J.M., Fuertes, A., Orozco, L., et al.Evidence for irreversible inhibition of glycogen synthase kinase-3β by tideglusibJ. Biol. Chem.287(2),893-904(2012)
Morales-Garcia, J.A., Luna-Medina, R., Alonso-Gil, S., et al.Glycogen synthase kinase 3 inhibition promotes adult hippocampal neurogenesis in vitro and in vivoACS Chem. Neurosci.3(11),963-971(2012)
Martinez, A., Gil, C., and Perez, D.I.Glycogen synthase kinase 3 inhibitors in the next horizon for Alzheimer's disease treatmentInt. J. Alzheimers Dis.,280502(2011)
