9-ING-41
Cat. No.：YN420093
CAS No. ：1034895-42-5
规格
价格(RMB)
库存
| 产品名称: | 9-ING-41 |
| CAS No.: | 1034895-42-5 |
| Chemical Name: | 3-(5-fluoro-3-benzofuranyl)-4-(5-methyl-5H-1,3-dioxolo[4,5-f]indol-7-yl)-1H-pyrrole-2,5-dione |
| Synonyms: | 9-ing-41 |
| 分子量: | 404.35 |
| 分子式: | C₂₂H₁₃FN₂O₅ |
| SMILES: | O=C(C(C1=COC2=CC=C(F)C=C12)=C3C4=CN(C)C5=C4C=C6C(OCO6)=C5)NC3=O |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | 9-ING-41 是一个有效的糖原合酶激酶 3 (GSK-3) 抑制剂。9-ING-41 通过靶向中心体和微管结合的 GSK-3β 诱导前期凋亡和细胞周期停滞。9-ING-41 具有抗肿瘤活性。 |
| IC50和靶点: | [{name:"GSK-3β:0.71 μM (IC50)"}] |
| In Vitro: | |
| In Vivo: | |
| Clinical Trial: | |
| Solvent & Solubility: |
Gaisina, I.N., Gallier, F., Ougolkov, A.V., et al.From a natural product lead to the identification of potent and selective benzofuran-3-yl-(indol-3-yl)maleimides as glycogen synthase kinase 3β inhibitors that suppress proliferation and survival of pancreatic cancer cellsJ. Med. Chem.52(7),1853-1863(2009)
Hilliard, T.S., Gaisina, I.N., Muehlbauer, A.G., et al.Glycogen synthase kinase 3 beta inhibitors induce apoptosis in ovarian cancer cells and inhibit in vivo tumor growthAnticancer Drugs22(10),978-985(2011)
Boren, J., Shryock, G., Fergis, A., et al.Inhibition of glycogen synthase kinase 3β blocks mesomesenchymal transition and attenuates Streptococcus pneumonia-mediated pleural injury in miceAm. J. Pathol.187(11),2461-2472(2017)
