IM-12
Cat. No.：YN420118
CAS No. ：1129669-05-1
规格
价格(RMB)
库存
| 产品名称: | IM-12 |
| CAS No.: | 1129669-05-1 |
| Chemical Name: | 3-[[2-(4-fluorophenyl)ethyl]amino]-1-methyl-4-(2-methyl-1H-indol-3-yl)-1H-pyrrole-2,5-dione |
| Synonyms: | IM 12 |
| 分子量: | 377.41 |
| 分子式: | C₂₂H₂₀FN₃O₂ |
| SMILES: | O=C(C(NCCC1=CC=C(F)C=C1)=C2C3=C(C)NC4=C3C=CC=C4)N(C)C2=O |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | IM-12 是GSK-3β的抑制剂，IC50值为 53 nM，可增强 Wnt 信号传导。 |
| IC50和靶点: | [{name:"GSK-3β:53 nM (IC50)"}] |
| In Vitro: | |
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| Clinical Trial: | |
| Solvent & Solubility: |
Brennführer, A., Neumann, H., Pews-Davtyan, A., et al.Catalytic and stoichiometric synthesis of novel 3-aminocarbonyl-, 3-alkoxycarbonyl-, and 3-amino-4-indolylmaleimidesJ. Org. Chem.2009(1),38-42(2009)
Schmöle, A.C., Brennführer, A., Karapetyan, G., et al.Novel indolylmaleimide acts as GSK-3β inhibitor in human neural progenitor cellsBioorg. Med. Chem.18(18),6785-6795(2010)
Eisenlöffel, C., Schmöle, A.C., Pews-Davtyan, A., et al.Interference of a novel indolylmaleimide with microtubules induces mitotic arrest and apoptosis in human progenitor and cancer cellsBiochem. Pharmacol.85(6),763-771(2013)
