SB 415286
Cat. No.:YN420214
产品名称: | SB 415286 |
CAS No.: | 264218-23-7 |
Chemical Name: | 3-[(3-chloro-4-hydroxyphenyl)amino]-4-(2-nitrophenyl)-1H-pyrrole-2,5-dione |
Synonyms: | 3-[(3-氯-4-羟苯基)氨基]-4-(2-硝苯基)-1H-吡咯-2,5-二酮,SB415286 |
分子量: | 359.72 |
分子式: | C₁₆H₁₀ClN₃O₅ |
SMILES: | O=C(C(NC1=CC=C(O)C(Cl)=C1)=C2C3=CC=CC=C3[N+]([O-])=O)NC2=O |
存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
运输: | Room temperature in continental US; may vary elsewhere. |
产品描述: | SB 415286 是一种有效的GSK-3α抑制剂,IC50值为 77.5 nM,Ki值为 30.75 nM;SB 415286 对人GSK-3α和GSK-3β的抑制效果相同。 |
IC50和靶点: | [{name:"hGSK-3α:77.5 nM (IC50)"},{name: "hGSK-3β:77.5 nM (IC50)"}] |
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In Vivo: | |
Clinical Trial: | |
Solvent & Solubility: |
Coghlan, M.P., Culbert, A.A., Cross, D.A.E., et al.Selective small molecule inhibitors or glycogen synthase kinase-3 modulate glycogen metabolism and gene transcriptionChem. Biol.7(10),793-803(2000)
Cross, D.A.E., Culbert, A.A., Chalmers, K.A., et al.Selective small-molecule inhibitors of glycogen synthase kinase-3 activity protect primary neurons from deathJ. Neurochem.77,94-102(2001)