SB 415286
Cat. No.：YN420214
CAS No. ：264218-23-7
规格
价格(RMB)
库存
| 产品名称: | SB 415286 |
| CAS No.: | 264218-23-7 |
| Chemical Name: | 3-[(3-chloro-4-hydroxyphenyl)amino]-4-(2-nitrophenyl)-1H-pyrrole-2,5-dione |
| Synonyms: | 3-[(3-氯-4-羟苯基)氨基]-4-(2-硝苯基)-1H-吡咯-2,5-二酮,SB415286 |
| 分子量: | 359.72 |
| 分子式: | C₁₆H₁₀ClN₃O₅ |
| SMILES: | O=C(C(NC1=CC=C(O)C(Cl)=C1)=C2C3=CC=CC=C3[N+]([O-])=O)NC2=O |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | SB 415286 是一种有效的GSK-3α抑制剂，IC50值为 77.5 nM，Ki值为 30.75 nM；SB 415286 对人GSK-3α和GSK-3β的抑制效果相同。 |
| IC50和靶点: | [{name:"hGSK-3α:77.5 nM (IC50)"},{name: "hGSK-3β:77.5 nM (IC50)"}] |
| In Vitro: | |
| In Vivo: | |
| Clinical Trial: | |
| Solvent & Solubility: |
Coghlan, M.P., Culbert, A.A., Cross, D.A.E., et al.Selective small molecule inhibitors or glycogen synthase kinase-3 modulate glycogen metabolism and gene transcriptionChem. Biol.7(10),793-803(2000)
Cross, D.A.E., Culbert, A.A., Chalmers, K.A., et al.Selective small-molecule inhibitors of glycogen synthase kinase-3 activity protect primary neurons from deathJ. Neurochem.77,94-102(2001)
