GSK 3 Inhibitor IX
Cat. No.：YN420052
CAS No. ：667463-62-9
规格
价格(RMB)
库存
| 产品名称: | GSK 3 Inhibitor IX |
| CAS No.: | 667463-62-9 |
| Chemical Name: | 6-bromo-3-[(3E)-1,3-dihydro-3-(hydroxyimino)-2H-indol-2-ylidene]-1,3-dihydro-(3Z)-2H-indol-2-one |
| Synonyms: | 6-Bromoindirubin-3'-oxime; BIO; MLS 2052 |
| 分子量: | 356.17 |
| 分子式: | C₁₆H₁₀BrN₃O₂ |
| SMILES: | O/N=C(C1=CC=CC=C1N2)/C2=C3C(NC4=C/3C=CC(Br)=C4)=O |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | GSK 3 Inhibitor IX (6-Bromoindirubin-3'-oxime; BIO) 是一种有效的，选择性的，可逆的，ATP 竞争性的GSK-3α/β和CDK1-cyclinB复合体抑制剂，能够抑制 (GSK-3α/β)/CDK1/CDK5 的活性，IC50值分别为 5 nM/320 nM/83 nM。 |
| IC50和靶点: | [{name:"GSK-3α:5 nM (IC50)"},{name: "GSK-3β:5 nM (IC50)"},{name: "CDK5/p35:80 nM (IC50)"},{name: "Cdk1/cyclin B:320 nM (IC50)"},{name: "cdk2/cyclin A:300 nM (IC50)"},{name: "Cdk4/cyclin D1:10 μM (IC50)"},{name: "MAPKK:10 μM (IC50)"},{name: "protein kinase Cα:12 μM (IC50)"}] |
| In Vitro: | |
| In Vivo: | |
| Clinical Trial: | |
| Solvent & Solubility: |
Meijer, L., Skaltsounis, A.L., Magiatis, P., et al.GSK-3-selective inhibitors derived from tyrian purple indirubinsChem. Biol.10(12),1255-1266(2003)
Polychronopoulos, P., Magiatis, P., Skaltsounis, A.L., et al.Structural basis for the synthesis of indirubins as potent and selective inhibitors of glycogen synthase kinase-3 and cyclin-dependent kinasesJ. Med. Chem.47(4),935-946(2004)
Sato, N., Meijer, L., Skaltsounis, L., et al.Maintenance of pluripotency in human and mouse embryonic stem cells through activation of Wnt signaling by a pharmacological GSK-3-specific inhibitorNat. Med.10(1),55-63(2004)
Tseng, A.S., Engel, F.B., and Keating, M.T.The GSK-3 inhibitor BIO promotes proliferation in mammalian cardiomyocytesChem. Biol.13(9),957-963(2006)
