CPI-455
Cat. No.：YN310010
CAS No. ：1628208-23-0
| 产品名称: | CPI-455 |
| CAS No.: | 1628208-23-0 |
| Chemical Name: | 4,7-dihydro-6-(1-methylethyl)-7-oxo-5-phenyl-pyrazolo[1,5-a]pyrimidine-3-carbonitrile |
| Synonyms: | CPI-455 HCl |
| 分子量: | 278.31 |
| 分子式: | C₁₆H₁₄N₄O |
| SMILES: | N#CC1=C2NC(C3=CC=CC=C3)=C(C(C)C)C(N2N=C1)=O |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | CPI-455 是一种特异性的泛KDM5抑制剂，对 KDM5A 的IC50为 10 nM，CPI-455 介导 KDM5 抑制，提高 H3K4me3 的整体水平，并减少多肿瘤细胞系模型中耐药的持久癌细胞的数量。 |
| IC50和靶点: | |
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| Clinical Trial: | |
| Solvent & Solubility: |
Vinogradova, M., Gehling, V.S., Gustafson, A., et al.An inhibitor of KDM5 demethylases reduces survival of drug-tolerant cancer cellsNat. Chem. Biol.12(7),531-538(2016)
Banelli, B., Daga, A., Forlani, A., et al.Small molecules targeting histone demethylase genes (KDMs) inhibit growth of temozolomide-resistant glioblastoma cellsOncotarget8(21),34896-34910(2017)
