KDM5-C70
Cat. No.：YN310150
CAS No. ：1596348-32-1
| 产品名称: | KDM5-C70 |
| CAS No.: | 1596348-32-1 |
| Chemical Name: | 2-[[[2-[[2-(dimethylamino)ethyl]ethylamino]-2-oxoethyl]amino]methyl]-4-pyridinecarboxylic acid, ethyl ester |
| Synonyms: | KDM5 inhibitor C70 |
| 分子量: | 336.43 |
| 分子式: | C₁₇H₂₈N₄O₃ |
| SMILES: | O=C(C1=CC(CNCC(N(CCN(C)C)CC)=O)=NC=C1)OCC |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | KDM5-C70 是一种 KDM5-C49 的乙酯衍生物，是一种有效的，细胞可渗透的泛KDM5组蛋白脱甲基酶抑制剂。KDM5-C70 在骨髓瘤细胞中具有抗增殖作用，从而导致 H3K4me3 水平在全基因组范围内升高。 |
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Tumber, A., Nuzzi, A., Hookway, E.S., et al.Potent and selective KDM5 inhibitor stops cellular demethylation of H3K4me3 at transcription start sites and proliferation of MM1S myeloma cellsCell Chem. Biol.24(3),371-380(2017)
